Most people around here may not of heard of the Virtual Boy, understandable considering the console was dead on arrival but it did have at least one good game.

Released in 1995, Wario Land takes place in the jungle where Wario is on an expedition for treasure using his trademark strong arm style along with novelty hats that contain powers and background jumping mechanics to take advantage of early 3D effects.

Health Warning: I'd advise not watching the entire video in one go to avoid migraine, although not as bad as the actual Virtual Boy but will still cause a few issues.

Pros
Solid platformer
Great mechanics that later become staples of Wario platformers
Best game on the Virtual Boy

Cons
It's on a Virtual Boy

Verdict
The best way to play this game is download the Gameboy mod version of this game on emulator, it's a good video game.