Lilo & Stitch is about an alien experiment who crash lands in Hawaii where he befriends a young girl named Lilo, it spawned into a series where both characters try and reform other experiments who go out of control, but few know that they also did an anime series as well, this is the story of Stitch!

Disney collaborated with Madhouse in 2008 to produce an anime version of Lilo & Stitch but instead of using the same character and same location, we move to Okinawa and this time we have a girl named Yuna, who looks like a rejected digi-destined.
To differentiate from the original series, the Stitch series doesn't use alien experiments instead using Japanese Yokai for character of the week episodes and very standard child cartoon friendly storylines for the other episodes. We even have a pink colored girlfriend for Stitch as well, however it doesn't take long to revert to the original formula of the former cartoon in later seasons & episodes.
So overall if you enjoyed Lilo & Stitch then you'll still find just as much enjoyment in this anime version.
Now to answer a question: Why is this in Cartoon Vault when it is an Anime?
This might surprise you but this is actually a sequel to the cartoon, as in Season 3 a grown-up Lilo visits Stitch in Okinawa. Under those circumstances it's hard to judge it as an anime when it's part of the show's canon.