Amy Winfrey, creator of the Traffic Cone Preservation Society, is a former animator for South Park and creator of number of famous webfilms, including Muffin Films, Big Bunny, and most recently Making Fiends, which became a Nicekodeon show. Highly, highly recommended. I've been watching her shows since middle school. Click here for Episode 1:

It's bright cheerfulness belies it's rather dark nature. You can still see the first 20 original (21 if you can find the hidden Thanksgiving post) webcasts for free here, which are, although a little poorer in animation quality, much quirkier and darker than the TV adaption aimed at a younger audience. But the TV show isn't dumbed down. Vendetta is still trying to do anything she can to kill Charlotte. If you like quirky humor and liked Zim, this might be just right for you.

Oh, and it's free. All of the shorts. (And les pantalones, if you've been watching Muffin)